“Current or ever HRT use
is partly correlated with
the decreased incidence of lung cancer in women”.1

Umbrella
What may the Hormone Therapy and Lung Cancer Umbrella include?

Depending on the Source (DotS) this Umbrella may include:

  • Cancer of the Lung
  • Hormone Replacement Therapy (HRT)
  • Hormone Therapy (HT)
  • Lung Cancer
  • Menopausal Hormone Therapy (MHT)

Studies

Is there an association between hormone therapy (HT) and the risk of lung cancer development?

In Despite Misperceptions, Hormone Therapy May Actually Reduce Risk of Lung Cancer, published 01 March 2023, the North American Menopause Society elaborate on:

Hormone Therapy and Lung Cancer“Study results have been inconsistent regarding the association between HT and the risk of lung cancer development, with some suggesting HT leads to greater risk and others stating it results in lower risk. This latest study, which is based on data from more than 38,000 postmenopausal women, sought to investigate the association between HT and lung cancer risk based on dosage. After 16 years of follow-up, the study’s researchers concluded that HT is not associated with an increased risk of lung cancer in postmenopausal women. In fact, it found that with a higher cumulative dosage of HT or a therapy duration that was longer than 5 years, the risk of developing lung cancer was lower”.2

In The Association Between Hormone Therapy and the Risk of Lung Cancer In Postmenopausal Women: A 16-Year Nationwide Population-Based Study: Conclusions, published May 2023, the authors conclude:

“Our results indicate that HT is not associated with the risk of lung cancer development in postmenopausal women; furthermore, a higher cumulative dosage and the long-term effects of HT reduce the risk of developing lung cancer”.3

Health Care Provider

If I choose to use HT what is my risk of lung cancer?

Different women who choose to use HT can have different risks of lung cancer. It may therefore be in your best interest to also choose to talk to your health care provider about this

In The 2022 Hormone Therapy Position Statement of The North American Menopause Society, published July 2022, the North American Menopause Society elaborate on:

“Hormone therapy remains the most effective treatment for vasomotor symptoms (VMS) and the genitourinary syndrome of menopause and has been shown to prevent bone loss and fracture. The risks of hormone therapy differ depending on type, dose, duration of use, route of administration, timing of initiation, and whether a progestogen is used. Treatment should be individualized using the best available evidence to maximize benefits and minimize risks, with periodic reevaluation of the benefits and risks of continuing therapy”.4

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Sources

Where may I find the Sources quoted?

You may find the Sources quoted at:

Sources

  1. Wen, H., Lin, X., Dun, D. The Association Between Different Hormone Replacement Therapy Use and the Incidence of Lung Cancer: A Systematic Review and Meta-Analysis: Conclusions. 28 February 2022 https://jtd.amegroups.com/article/view/61565/html Accessed: 07 November 2023
  2. Despite Misperceptions, Hormone Therapy May Actually Reduce Risk of Lung Cancer. 01 March 2023. North American Menopause Society https://www.menopause.org/docs/default-source/press-release/hormone-therapy-and-lung-cancer.pdf Accessed: 07 November 2023
  3. Wu, C-C., Chung, C-H., Tzeng, N-S., Wu, M-J., Tsao, C-H., et al. The Association Between Hormone Therapy and the Risk of Lung Cancer In Postmenopausal Women: A 16-Year Nationwide Population-Based Study: Conclusions. May 2023 https://journals.lww.com/menopausejournal/Abstract/2023/05000/The_association_between_hormone_therapy_and_the.10.aspx Accessed: 07 November 2023
  4. The 2022 Hormone Therapy Position Statement of The North American Menopause Society. July 2022. North American Menopause Society https://journals.lww.com/menopausejournal/Abstract/2022/07000/The_2022_hormone_therapy_position_statement_of_The.4.aspx Accessed: 07 November 2023
Topic Last Updated: 07 November 2023 – Topic Last Reviewed: 07 November 2023

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